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What is asthma?

Asthma is a heterogeneous respiratory condition characterized by chronic inflammation of the airways. The inflammation causes the airways to become swollen, narrow, and extremely sensitive and irritated, restricting airflow to the lungs.

 

Asthma affects approximately 300 million people worldwide and causes about a thousand deaths per day¹. In Brazil, it is estimated that 20 million people have the disease.

 

Asthma can be classified according to severity – mild, moderate, or severe – or according to the causative agent (phenotype) – allergic, non-allergic, with persistent airflow limitation, associated with obesity, adult-onset, and with predominant cough.

MAIN CAUSES

The exact cause of asthma is not yet fully understood, but it is believed to be a combination of genetic and environmental factors. Some risk factors include:

  • Genetic factors: People with close relatives who have asthma or allergies are more likely to develop the disease.
  • Exposure to allergens: Dust mites, pollen, pet dander, and mold are some of the most common allergens that can trigger asthma attacks.
  • Air pollution: Exposure to air pollution can worsen asthma symptoms and increase the risk of developing the disease.

MAIN SYMPTOMS

Symptoms and airflow limitation can vary over time and in intensity. These variations are usually triggered by factors such as exercise, exposure to allergens, climate changes, or respiratory infections:

  • Shortness of breath: difficulty breathing, a feeling of not being able to get enough air;
  • Cough: dry cough or cough with phlegm, especially at night or after physical activity;
  • Wheezing: a high-pitched, whistling sound when breathing, usually more noticeable when exhaling;
  • Chest tightness: a feeling of pressure or tightness in the chest;
  • Other symptoms: fatigue, anxiety, difficulty sleeping, and limitations in daily activities.

TREATMENT

Asthma treatment has two goals: to control symptoms and prevent attacks and loss of lung function. Approaches include controller and reliever medications, recommended by the doctor according to the severity of the disease.

 

  • Controllers: These medications are indicated to reduce airway inflammation, control symptoms, and prevent attacks;

    This category includes corticosteroids (inhaled and oral), long-acting bronchodilators, and biologics. 

    Current treatment guidelines recommend that controller therapies combine bronchodilators and inhaled corticosteroids.

 

  • Relievers: These are indicated for rapid symptom relief and reversal of bronchoconstriction, such as short-acting bronchodilators.

This material was elaborated by Chiesi Farmacêutica Ltda. Medical-Scientific Department (DMC) with the sole purpose of providing information. Remember that in any situation, only your doctor can prescribe the right medicines for you and advise you on the best therapy.